Julian Draxler, Idrissa Gueye and Kylian Mbappe added another three in the second half while Angers pulled one back in the 52nd minute.
Jiangsu showed its well-balanced, attacking firepower, with seven players scoring in double figures, led by Sun Li's 18.
In the 25km race, China's Gao Chongchong and Zhang Jiajing won the men's and women's group respectively.
Kitata, 24, managed to dash to the finishing line first, one second before Kenya's Vincent Kipchumba.
"All the time I kept myself in the back to attack when I needed to," said Kitata. "When I went, I tried to push the pace more than before. I went into the last lap to beat the others."
Saturday ended with Newcastle United winning 3-1 at home to Burnley thanks to an excellent display from winger Allan Saint-Maximin. The Frenchman scored his side's first goal and then set up Callum Wilson for Newcastle's second of the game just four minutes after Ashley Westwood's 61st minute equalizer for the visitors.
Cavani was left out of the Celeste squad by head coach Oscar Tabarez, paying the price for having not played since March.
His initial spell at the helm ended after the 1990 World Cup, however, Tabarez returned in 2006 and immediately turned the team's fortunes around.
Jiangsu played a more aggressive game in Tuesday's faceoff with Shanghai, which had led the championship group before the third round. In the 70th minute, Wu Chengshu received a pass from the left side and rifled an effort into the net, helping Jiangsu gain a 1-0 lead.
That performance has put Athletic coach Gaizka Garitano under pressure and both he and Machin need wins to assure they are still in their jobs after the international break.
"He is now playing more regularly and doesn't have any injury concerns which bodes well for us."